INFERNET

Project Infernet: Co-funded by the European Union's H2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement number 734439. Coordinator: Andrea Pagnani.

Project web-site: https://www.infernet.eu/

Research Fields:

1. INFERENCE OF INTERACTION NETWORKS FROM DATA
A major challenge in computational biology is to use data to unveil the interrelations between biological processes and the molecules contributing to them in terms of regulatory networks. The analysis will produce topological description (who is directly coupled with whom?), and quantitative functional description (how things interact?).

2. ANALYSIS OF STATIC AND DYNAMICAL PROCESSES ON NETWORKS
INFERNET aims at developing distributed algorithmic techniques for a few key inference problems in molecular systems biology such as large scale models of proliferative metabolism, and large scale models of
post-transcriptional microRNA mediated regulation.

Application Domains:

1. INFERENCE AND MODELING OF MULTI-SCALE BIOLOGICAL NETWORKS
INFERNET research products will be applied to inference from scarce, noisy data sets where a central question is the design of adequate null models to assign statistical significance values to the inferred model parameters, to the sparse graphical model learning, and to the taming with the algorithmic complexity.

2. RATIONAL DESIGN OF BIOLOGICAL MOLECULES
The project will exploit the co-evolutionary information gathered either from existing databases of thousands of functionally active mutants, to build reliable multivariate models of the observed sequence variability to predict new functional molecules.

3. QUANTITATIVE STUDY OF CELL ENERGETICS IN PROLIFERATIVE REGIMES
Constraint-based models are powerful mathematical tools that are used to examine metabolic networks at genome scale, and in particular to formulate testable hypotheses on aberrant regimes such as
proliferative cancer.

4. FUNCTIONAL STATES OF LARGE-SCALE REGULATORY NETWORKS
Characterization of regulatory mechanisms in post-transcriptional microRNA mediated networks to: (i) unveil their physical origin, magnitude and dependence on kinetic parameters and (ii) under which conditions it performs other regulatory mechanisms