EARLY-STAGE RESEARCHER WITH CELL CULTURE AND BIOCHEMISTRY BACKGROUND NEW!!

The Statistical Inference and Biological Modeling lab @IIGM, headed by Andrea Pagnani, is seeking a highly motivated early-stage researcher with a strong background in mammalian cell culture, metabolic gene modification, cancer metabolism, and large-scale metabolic modeling. The Italian Institute for Genomic Medicine (IIGM, www.iigm.it), is located at the FPO IRCCS Candiolo Cancer Institute, (Turin), Italy (www.research.fpoircc.it). The main goal of IIGM is to foster and develop excellence in translational medicine, immunology, genomic research, and education, with a strong focus on cancer. The institute provides high-level scientific education and access to state-of-the-art research facilities.

The core activity of the Statistical Inference and Computational Biology unit is the development of statistical mechanics-inspired computational techniques for the analysis of experimental datasets and in particular for inference problems in complex biological systems.

Research

We encourage applications from talented scientists interested in gaining experience in a growing multidisciplinary and dynamic research environment that integrates expertise in hard sciences such as Physics and Mathematics, and computational biology in the context of large-scale inference from biological sequence data.

Position

The candidate will learn how to combine various advanced statistical methods and tools specifically tailored to the problem of analyzing large datasets of multiple sequence alignment data of coding sequences with the final goal of producing a statistical model of the underlying data set with generative characteristics.

Requirements

• Mammalian cell culture

• Analytics techniques for biochemistry (electrophoresis, western blot, protein quantification)

• Flow cytometry

• Experience in multivariate statistics;

• Good communication skills and self-motivation;

• Fluent in spoken and written English

Application

To apply for this position please submit:

• a cover letter (in English), describing research experiences, interests, motivation

• an updated Curriculum Vitae

Other information

Offered contract: 1 year fellowship (renewable).

Offered positions: no. 01 - available immediately, the call will remain open until the position is filled.

Please send your application, recommendation letter (if available) and curriculum vitae to:
Prof. A Pagnani, email: andrea.pagnani@iigm.it

Open post-doc position in "Genetically-encoded fluorogenic biosensor for drug discovery"
A post-doc position in "Genetically-encoded fluorogenic biosensors for drug discovery" is available at the laboratory of Chemical Biology at the Italian Institute for Genomic Medicine -IIGM- (Candiolo, 10060, Italy). IIGM supports young scientist in the area of human genomics and life sciences. IIGM is centrally located within the biomedical research hub with close links top Italian Academic Institutions (University of Turin, Polytechnic University of Turin) and the Candiolo Cancer Institute.
Research
The field of drug discovery for human disease treatment has grown particularly fast in the last two decades. Rapid identification of novel biomarkers and small molecule inhibitors has been made possible by major improvements in both genetic screening and functional genomics technologies. Nevertheless, gene functions interrogation at elevated throughput remains difficult for complex cellular phenotypes. This research project aims to identify novel biomarkers and small molecules controlling intracellular trafficking pathways by combining novel genetically-encoded biosensors and CRISPR-based genetic screening.

Position
We are seeking for a highly motivated post-doc researcher (within 2 years from attainment of her/his PhD) to be integrated in a multidisciplinary team of scientists. The ideal candidate should have a degree in Biotechnology, Bioengineering, Biochemist, or a related field. The candidate must have experience in at least one of the following disciplines: i) fluorescent microscopy and cytofluorimetry ii) molecular biology and biochemistry, ii) molecular modelling and bioinformatics. Knowledge in scientific illustration software is a major plus. The successful scholar will be trained in protein engineering techniques, functional screening and she/he will design novel assay enabling automated interrogation of membrane trafficking pathways. This project will be integrated with other research line in the lab focusing on biomarker discovery and drug development.
Application
The position is available immediately and applicants will be considered until the vacancy is filled.

For further enquires please contact: Carlo C. Campa (carlocosimo.campa@iigm.it).