ITALIAN INSTITUTE FOR GENOMIC MEDICINE

Research, Innovation, Integration



IN THE SPOTLIGHT
New Scientific Director

The IIGM Foundation welcomes its new Scientific Director Saverio Minucci, Professor of General Pathology at the University of Milan and head of the Chromatin Alterations in Tumorigenesis Research Unit at IEO - European Institute of Oncology
OPEN POSITION 2 NEW!!
Early-stage researchers with mathematics/physics background
The Statistical Inference and Biological Modeling lab is seeking two highly motivated early-stage researchers with a strong background in mathematics/physics who are interested in gaining experience in a growing multidisciplinary and dynamic research environment that integrates Physics, Mathematics, and computational biology in the context of large-scale inference from biological sequence data.
See "Job opportunities".
IN THE SPOTLIGHT
FOXA1 regulates alternative splicing in prostate cancer

The study identified a new role for the already known prostate cancer oncogene FOXA1, demonstrating its key function in controlling alternative "splicing," and thus influencing the emergence of gene variants in cancer. The identification of such variants may help predict disease prognosis, and the variants themselves may represent new drug targets to improve patient survival.

Cell Rep. 2022

IN THE SPOTLIGHT
Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B

The study shows that type I interferons (IFNs-I) act as molecular hubs of resistance during immunogenic chemotherapy, triggering the epigenetic regulator demethylase 1B (KDM1B) to promote an adaptive, yet reversible, transcriptional rewiring of cancer cells towards stemness and immune escape.

Nat. Immunol 2022