ITALIAN INSTITUTE FOR GENOMIC MEDICINE

Research, Innovation, Integration
IN THE SPOTLIGHT
Trapezio - Paving the way to research excellence and talent attraction
The Italian Institute for Genomic Medicine (IIGM) is eligible to receive proposals as Host Institution for projects in response to TRAPEZIO Target 2: MSCA Seal of Excellence - European H2020 Individual Fellowships and Horizon Europe Postdoctoral Fellowships. Conditions and requirements here.
IN THE SPOTLIGHT
Memory CD8+ T cell, B cell responses, and SARS-CoV-2 protection after mRNA vaccination
Current SARS-CoV-2 vaccine recipients differ in infection history and the magnitude of their elicited antibody response.
A large human cohort distinguished by these parameters are queried for effector memory T cell subsets, memory B cells and ability to recognize epitopes from SARS-CoV-2 variants of concern.
IN THE SPOTLIGHT
FOXA1 regulates alternative splicing in prostate cancer

The study identified a new role for the already known prostate cancer oncogene FOXA1, demonstrating its key function in controlling alternative "splicing," and thus influencing the emergence of gene variants in cancer. The identification of such variants may help predict disease prognosis, and the variants themselves may represent new drug targets to improve patient survival.

Cell Rep. 2022
IN THE SPOTLIGHT
Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B

The study shows that type I interferons (IFNs-I) act as molecular hubs of resistance during immunogenic chemotherapy, triggering the epigenetic regulator demethylase 1B (KDM1B) to promote an adaptive, yet reversible, transcriptional rewiring of cancer cells towards stemness and immune escape.
Nat. Immunol 2022