Research assistant in CRISPR‑engineered cellular models of genetic disorders
Pubblicato: 19.05.2026
Chiusura: —
Company Description
IIGM is located at the FPO IRCCS Candiolo Cancer Institute, Candiolo (Turin – Italy). The main goal of IIGM (https://www.iigm.it/) is to foster and develop excellence in research and education, with special reference to human diseases biology and biomarker discovery. The institute provides high-level scientific education for students and post-doctoral fellows, and access to state-of-the-art research facilities and international networks.
Gender Equality Plan: diversity is our legacy and our future. Be part of it. At IIGM diversity is an integral part of our culture and identity and for this we have adopted a plan for gender equality (GEP). We promote diversity and inclusion because we recognize that they are a source of strength and competitive advantage.
Position
The Chemical Biology Lab at the Italian Institute for Genomic Medicine (IIGM) is seeking highly motivated candidates at all levels of seniority (predoc, postdoc) to work in high-content imaging and analysis with a focus on cell-to-cell heterogeneity and phenotypic variability in membrane trafficking. The laboratory investigates key aspects of Rab GTPases and their involvement in hereditary genetic diseases. The project aims to generate cellular model of steroid-resistant nephrotic syndrome (SRNS) disease and perform genotype-phenotype correlation analysis using molecular and computational tools developed in the lab. By integrating phenotypic mapping with biochemical and genetic information, we seek to elucidate the biological functions of rare genetic variants causing steroid-resistant nephrotic syndrome. The Institute provides state-of-the-art genomics, single-cell genomics sequencing platforms and high-content imaging platforms.
The successful candidates will take on the following responsibilities:
• Generate isogenic HK-2 cell lines harbouring genetic mutations causing SRNS disease.
• Perform immunostaining of Rab GTPase and other proteins involved in intracellular trafficking.
• Perform biochemical experiments on Rab GTPase regulators.
• Conduct image acquisition using automated microscopy systems.
• Perform image data analysis of high-dimensional dataset.
• Contribute to ongoing research group activities and collaborative projects.
Qualifications and requirements:
• Bachelor’s degree in biotechnology, biology, medicine, chemical biology, pharmacy or a related field;
• 1 year experience in at least one of the following subjects:
(i) generation of knock-in CRISPR/Cas9 edited human cells
(ii) protein purification
(iii) high-content imaging and data analysis
(iv) mammalian tissue culture (cells and/or organoids)
• good command of the English language
• knowledge of Italian is an advantage, but not strictly necessary
Soft skills:
• curiosity and active learning
• critical thinking and problem-solving
• time management
• adaptability and flexibility
• effective communication in cross-cultural environments
Interested candidates should include:
• curriculum vitae (in PDF format in Italian or English)
• cover letter
• research proposal (for postdoc applicants only)
• certificates, transcripts including all grades of your previous qualifications, and a list of publications
Positions: no. 01
Offered contract: Coordinated and Continuous Collaboration contract (Co.Co.Co.) on a project basis with flexible working options. Competitive remuneration based on the candidate’s personal qualifications.